After spending about three hours at the restaurant, the actresses were all seen leaving separately.
Aniston was spotted sneaking out the back door of the restaurant. The 45-year-old actress left the restaurant with her kept her head down while in the backseat of a chauffeur-driven Mercedes, which was crowded by the paparazzi.
Prior to this, Cox was also spotted having lunch with her former husband David Arquette on this same day.
A source told E! News that while 45-year-old Aniston, 50-year-old Cox and 50-year-old Kudrow "are great friends," the dinner gathering was "not indicative of anything."
Earlier this year, "Friends" co-creator Marta Kauffman told the publication there is no truth to the rumors that Aniston, Cox and Kudrow along with Matthew Perry, Matt LeBlanc and David Schwimmer may eventually be reunited for another season of the show.
"I'm going to clear this up. It's not happening!" Kauffman explained at the red carpet screening of the Lifetime movie about mental illness entitled "Call Me Crazy," which premiered on the network in April.
Cox also told David Letterman in April "Friends" that the reunion is "not gonna happen," New York Daily News reported.
"You're sick of the question, aren't you?" Letterman asked.
"Only because once you say, 'Well, I'd like it,' then they have to contact every other castmember and be like, 'Courteney's into it!' And then I get in trouble," Cox replied.
"Let me tell you something. There's six friends and I've been trying to put together a cast dinner for 10 years. It doesn't happen," she added.
Aired on NBC from September 22, 1994 to May 6, 2004, "Friends" featured a story revolving around a circle of pals living in Manhattan and was about "that time in your life when your friends are your family and once you have a family," according to Kauffman, "there's no need anymore."